4: Intern Med. 2007;46(2):75-6\. Epub 2007 Jan 15.
Segmental muscular atrophy in a patient with post polio syndrome.
* Maeda K,
* Joko M.
Department of Neurology, Uji Tokushukai Hospital. kengo@belle.shiga-med.ac.jp
PMID: 17220601 [PubMed - indexed for MEDLINE]
3: Neurology. 2007 Jan 9;68(2):141-5.
Incidence of ALS in Lombardy, Italy.
* Beghi E,
* Millul A,
* Micheli A,
* Vitelli E,
* Logroscino G,
* SLALOM Group.
Clinica Neurologica, Monza, Italy. beghi@marionegri.it
OBJECTIVE: To assess the incidence and trends of ALS in a large population at risk. METHODS: This study was performed in nine provinces of Lombardy in Northern Italy (population 4,947,554). Patients with newly diagnosed ALS were enrolled during the period 1998 to 2002 through a prospective regional register. For each patient, the main demographic and clinical information was collected by the caring physicians and reviewed by a panel of experts according to the original and revised El Escorial diagnostic criteria. Overall, age- and sex-specific and standardized annual incidence rates were calculated for the entire population and for each year and province separately. RESULTS: We studied 517 patients (M:F ratio 1.3) aged 18 to 92 years (mean 63.6). Onset of symptoms was bulbar in 29% of cases. ALS was definite in 45%, probable in 27%, probable laboratory supported in 3.5%, possible in 15%, and suspected in 10%. Mean disease duration at diagnosis was 10.6 months. The standardized incidence rate was 2.09 per 100,000/year (95% CI: 1.17 to 3.18). The rate, which was 2.43 in men and 1.76 in women, tended to increase up to ages 65 to 74 and to decrease thereafter. The rate was unchanged over time and presented moderate variations across provinces. The incidence rate of definite ALS was 0.93 (spinal-onset ALS 1.35; bulbar-onset ALS 0.74) and was consistently higher in men with spinal-onset ALS vs men with bulbar-onset ALS and women. CONCLUSIONS: The incidence of ALS varied according to age, sex, and site of onset. No temporal and geographic clusters were detected over a 5-year period.
PMID: 17210896 [PubMed - indexed for MEDLINE]
3: Neurology. 2007 Jan 9;68(2):141-5.
Incidence of ALS in Lombardy, Italy.
* Beghi E,
* Millul A,
* Micheli A,
* Vitelli E,
* Logroscino G,
* SLALOM Group.
Clinica Neurologica, Monza, Italy.beghi@marionegri.it
OBJECTIVE: To assess the incidence and trends of ALS in a large population at risk. METHODS: This study was performed in nine provinces of Lombardy in Northern Italy (population 4,947,554). Patients with newly diagnosed ALS were enrolled during the period 1998 to 2002 through a prospective regional register. For each patient, the main demographic and clinical information was collected by the caring physicians and reviewed by a panel of experts according to the original and revised El Escorial diagnostic criteria. Overall, age- and sex-specific and standardized annual incidence rates were calculated for the entire population and for each year and province separately. RESULTS: We studied 517 patients (M:F ratio 1.3) aged 18 to 92 years (mean 63.6). Onset of symptoms was bulbar in 29% of cases. ALS was definite in 45%, probable in 27%, probable laboratory supported in 3.5%, possible in 15%, and suspected in 10%. Mean disease duration at diagnosis was 10.6 months. The standardized incidence rate was 2.09 per 100,000/year (95% CI: 1.17 to 3.18). The rate, which was 2.43 in men and 1.76 in women, tended to increase up to ages 65 to 74 and to decrease thereafter. The rate was unchanged over time and presented moderate variations across provinces. The incidence rate of definite ALS was 0.93 (spinal-onset ALS 1.35; bulbar-onset ALS 0.74) and was consistently higher in men with spinal-onset ALS vs men with bulbar-onset ALS and women. CONCLUSIONS: The incidence of ALS varied according to age, sex, and site of onset. No temporal and geographic clusters were detected over a 5-year period.
PMID: 17210896 [PubMed - indexed for MEDLINE]
2: Neurology. 2007 Jan 9;68(2):122-7.
The value of interictal diffusion-weighted imaging in lateralizing temporal lobe epilepsy.
* Wehner T,
* Lapresto E,
* Tkach J,
* Liu P,
* Bingaman W,
* Prayson RA,
* Ruggieri P,
* Diehl B.
Epilepsy Center-S10, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH 44195, USA. wehnert@ccf.org
BACKGROUND: A subgroup of patients with nonlesional temporal lobe epilepsy (TLE) has no evidence of hippocampal sclerosis on standard temporal lobe protocol MRI. OBJECTIVE: To investigate whether interictal diffusion-weighted imaging adds lateralizing information in patients with TLE with and without lateralizing conventional MRI. METHODS: We studied 22 patients (9 right, 13 left TLE) who had undergone temporal lobectomy and 18 control subjects. We measured hippocampal volumes on high- resolution coronal magnetization-prepared rapid gradient echo scans. Apparent diffusion coefficients (ADCs) for the entire hippocampus and three arbitrarily defined areas of interest within the hippocampal head, body, and tail were measured from the coregistered ADC map. Pathology was reviewed and correlated with imaging findings. RESULTS: Fourteen of 22 patients had hippocampal atrophy on MRI (defined as volume asymmetry greater than 2 SDs compared with asymmetry in the control group). Overall, resected hippocampi (n = 22) were significantly smaller than contralateral hippocampi as well as ipsilateral hippocampi in controls. ADCs were significantly higher in resected hippocampi than contralateral hippocampi as well as ipsilateral hippocampi in controls. These differences were also observed within the three areas of interest. ADCs in the hippocampi contralateral to the epileptogenic zone (n = 22) were also higher than in ipsilateral hippocampi in controls. In the subgroup of eight patients with nonlateralizing conventional MRIs, ADCs of resected hippocampi were not significantly different compared with the contralateral side. Pathology in these patients revealed gliosis only without apparent neuron loss. CONCLUSION: Interictal apparent diffusion coefficients confirm lateralization in patients with hippocampal atrophy on standard temporal lobe protocol MRI. However, they do not provide lateralizing information in patients with nonlateralizing conventional MRI.
PMID: 17210892 [PubMed - indexed for MEDLINE]
1: Lancet Neurol. 2007 Jan;6(1):18-9. Substance via MeSH,
Neuromuscular disorders: therapeutic advances.
* Talbot K.
Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Oxford, OX2 6HE, UK. kevin.talbot@clneuro.ox.ac.uk
PMID: 17166796 [PubMed - indexed for MEDLINE]
Segmental muscular atrophy in a patient with post polio syndrome.
* Maeda K,
* Joko M.
Department of Neurology, Uji Tokushukai Hospital. kengo@belle.shiga-med.ac.jp
PMID: 17220601 [PubMed - indexed for MEDLINE]
3: Neurology. 2007 Jan 9;68(2):141-5.
Incidence of ALS in Lombardy, Italy.
* Beghi E,
* Millul A,
* Micheli A,
* Vitelli E,
* Logroscino G,
* SLALOM Group.
Clinica Neurologica, Monza, Italy. beghi@marionegri.it
OBJECTIVE: To assess the incidence and trends of ALS in a large population at risk. METHODS: This study was performed in nine provinces of Lombardy in Northern Italy (population 4,947,554). Patients with newly diagnosed ALS were enrolled during the period 1998 to 2002 through a prospective regional register. For each patient, the main demographic and clinical information was collected by the caring physicians and reviewed by a panel of experts according to the original and revised El Escorial diagnostic criteria. Overall, age- and sex-specific and standardized annual incidence rates were calculated for the entire population and for each year and province separately. RESULTS: We studied 517 patients (M:F ratio 1.3) aged 18 to 92 years (mean 63.6). Onset of symptoms was bulbar in 29% of cases. ALS was definite in 45%, probable in 27%, probable laboratory supported in 3.5%, possible in 15%, and suspected in 10%. Mean disease duration at diagnosis was 10.6 months. The standardized incidence rate was 2.09 per 100,000/year (95% CI: 1.17 to 3.18). The rate, which was 2.43 in men and 1.76 in women, tended to increase up to ages 65 to 74 and to decrease thereafter. The rate was unchanged over time and presented moderate variations across provinces. The incidence rate of definite ALS was 0.93 (spinal-onset ALS 1.35; bulbar-onset ALS 0.74) and was consistently higher in men with spinal-onset ALS vs men with bulbar-onset ALS and women. CONCLUSIONS: The incidence of ALS varied according to age, sex, and site of onset. No temporal and geographic clusters were detected over a 5-year period.
PMID: 17210896 [PubMed - indexed for MEDLINE]
3: Neurology. 2007 Jan 9;68(2):141-5.
Incidence of ALS in Lombardy, Italy.
* Beghi E,
* Millul A,
* Micheli A,
* Vitelli E,
* Logroscino G,
* SLALOM Group.
Clinica Neurologica, Monza, Italy.beghi@marionegri.it
OBJECTIVE: To assess the incidence and trends of ALS in a large population at risk. METHODS: This study was performed in nine provinces of Lombardy in Northern Italy (population 4,947,554). Patients with newly diagnosed ALS were enrolled during the period 1998 to 2002 through a prospective regional register. For each patient, the main demographic and clinical information was collected by the caring physicians and reviewed by a panel of experts according to the original and revised El Escorial diagnostic criteria. Overall, age- and sex-specific and standardized annual incidence rates were calculated for the entire population and for each year and province separately. RESULTS: We studied 517 patients (M:F ratio 1.3) aged 18 to 92 years (mean 63.6). Onset of symptoms was bulbar in 29% of cases. ALS was definite in 45%, probable in 27%, probable laboratory supported in 3.5%, possible in 15%, and suspected in 10%. Mean disease duration at diagnosis was 10.6 months. The standardized incidence rate was 2.09 per 100,000/year (95% CI: 1.17 to 3.18). The rate, which was 2.43 in men and 1.76 in women, tended to increase up to ages 65 to 74 and to decrease thereafter. The rate was unchanged over time and presented moderate variations across provinces. The incidence rate of definite ALS was 0.93 (spinal-onset ALS 1.35; bulbar-onset ALS 0.74) and was consistently higher in men with spinal-onset ALS vs men with bulbar-onset ALS and women. CONCLUSIONS: The incidence of ALS varied according to age, sex, and site of onset. No temporal and geographic clusters were detected over a 5-year period.
PMID: 17210896 [PubMed - indexed for MEDLINE]
2: Neurology. 2007 Jan 9;68(2):122-7.
The value of interictal diffusion-weighted imaging in lateralizing temporal lobe epilepsy.
* Wehner T,
* Lapresto E,
* Tkach J,
* Liu P,
* Bingaman W,
* Prayson RA,
* Ruggieri P,
* Diehl B.
Epilepsy Center-S10, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH 44195, USA. wehnert@ccf.org
BACKGROUND: A subgroup of patients with nonlesional temporal lobe epilepsy (TLE) has no evidence of hippocampal sclerosis on standard temporal lobe protocol MRI. OBJECTIVE: To investigate whether interictal diffusion-weighted imaging adds lateralizing information in patients with TLE with and without lateralizing conventional MRI. METHODS: We studied 22 patients (9 right, 13 left TLE) who had undergone temporal lobectomy and 18 control subjects. We measured hippocampal volumes on high- resolution coronal magnetization-prepared rapid gradient echo scans. Apparent diffusion coefficients (ADCs) for the entire hippocampus and three arbitrarily defined areas of interest within the hippocampal head, body, and tail were measured from the coregistered ADC map. Pathology was reviewed and correlated with imaging findings. RESULTS: Fourteen of 22 patients had hippocampal atrophy on MRI (defined as volume asymmetry greater than 2 SDs compared with asymmetry in the control group). Overall, resected hippocampi (n = 22) were significantly smaller than contralateral hippocampi as well as ipsilateral hippocampi in controls. ADCs were significantly higher in resected hippocampi than contralateral hippocampi as well as ipsilateral hippocampi in controls. These differences were also observed within the three areas of interest. ADCs in the hippocampi contralateral to the epileptogenic zone (n = 22) were also higher than in ipsilateral hippocampi in controls. In the subgroup of eight patients with nonlateralizing conventional MRIs, ADCs of resected hippocampi were not significantly different compared with the contralateral side. Pathology in these patients revealed gliosis only without apparent neuron loss. CONCLUSION: Interictal apparent diffusion coefficients confirm lateralization in patients with hippocampal atrophy on standard temporal lobe protocol MRI. However, they do not provide lateralizing information in patients with nonlateralizing conventional MRI.
PMID: 17210892 [PubMed - indexed for MEDLINE]
1: Lancet Neurol. 2007 Jan;6(1):18-9. Substance via MeSH,
Neuromuscular disorders: therapeutic advances.
* Talbot K.
Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Oxford, OX2 6HE, UK. kevin.talbot@clneuro.ox.ac.uk
PMID: 17166796 [PubMed - indexed for MEDLINE]
